Dr Alison Isaacs

Post Doctoral Research in Medecine Assistant

Areas of interest

Host-pathogen interactions, insecticide resistance of Anopheles gambiae

Background

Alison Isaacs obtained a BSc in biology from Tufts University in 2006 and a PhD in Biomedical Sciences from the University of California Irvine in 2011.  Her thesis project aimed to create a genetically-modified mosquito that does not transmit the human malaria parasite Plasmodium falciparum.  As a Pasteur Cantarini fellow, she continued to investigate host-parasite interactions and mosquito population genetics at the Pasteur Institute in Paris.  She is currently working as a post-doctoral research assistant with Dr. Martin Donnelly in the Vector Group.

Research in Medecine

My current research focus is identifying and characterizing insecticide resistance mechanisms in Anopheles gambiaemosquitoes from Eastern Uganda.  Furthermore, I aim to study the relationships between insecticide resistance, mosquito fitness, and P. falciparum population genetics.

Publications

  • Selected publications

    Isaacs AT, Jasinskiene N, Tretiakov M, Thiery I, Zettor A, Bourgouin C, & James AA.  Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development. (2012) Proc Natl Acad Sci U S A 109, E1922.

    Franz AW, Jasinskiene N, Sanchez-Vargas I, Isaacs AT, Smith MR, Khoo CC, Heersink MS, James AA, & Olson KE.  Comparison of transgene expression in Aedes aegypti generated by mariner Mos1 transposition and PhiC31 site-directed recombination. (2011) Insect Mol Biol 20(5):587-598.

    Isaacs AT, Li F, Jasinskiene N, Chen X, Nirmala X, Marinotti O, Vinetz JM, & James AA.  Engineered resistance to Plasmodium falciparum development in transgenic Anopheles stephensi. (2011) PLoS Pathog 7(4):e1002017.

    Amenya DA, Bonizzoni M, Isaacs AT, Jasinskiene N, Chen H, Marinotti O, Yan G, & James AA.  Comparative fitness assessment of Anopheles stephensi transgenic lines receptive to site-specific integration. (2010) Insect Mol Biol 19(2):263-269.

    Wiley CD, Matundan HH, Duselis AR, Isaacs AT, & Vrana PB.  Patterns of hybrid loss of imprinting reveal tissue- and cluster-specific regulation. (2008) PLoS One 3(10):e3572.

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