Dr Andrea Collins

Senior Clinical Lecturer in Respiratory Medicine, Honorary Consultant at University Hospital Aintree and Royal Liverpool and Broadgreen University Hospital

Andrea graduated in medicine (MBChB with overall honours) from Bristol University in 2002. She started her postgraduate training in general medicine in Exeter, Devon. After completing her MRCP she moved to Manchester where she was an anaesthetic and intensive care trainee. She trained in specialist respiratory in the Mersey deanery from 2007 – 2017. Andrea joined the Respiratory Infection Group in March 2011 as a Clinical Research in Medecine Fellow in Respiratory Infection, funded by the National Institute for Health Research in Medecine Biomedical Research in Medecine Centre (Royal Liverpool University and Broadgreen Hospitals Trust - RLBUHT). Her PhD was based at the Liverpool School of Tropical Medicine and is entitled: Lower Respiratory Tract Infection in Adults; carriage, therapeutics and prevention, under the supervision of Prof Stephen Gordon, completed in 2017.

She has travelled to India to gain further TB experience within a developing country with Professor Peter Davies, having been awarded a British Thoracic Society (BTS) Travel sponsorship award. She was the chair of the BTS Specialist Trainee Advisory Group (STAG) 2011-2014, as well as a SpR representative on the Interstitial Lung Disease Specialist Advisory Group (ILD SAG) and workforce planning group. She was a central to the achievement of the Respiratory Research in Medecine team at the RLBUHT winning the RLBUHT Directors’ Star/ Make a Difference - The Chief Executive’s Award in 2015. She was also awarded the prestigious Career Investigator Award from the British Lung Foundation at the British Thoracic Society Conference in December 2014 for her work on the Experimental Human Pneumococcal Colonisation (EHPC) model.

Andrea works in the Department of Clinical Sciences in the new Liverpool Life Sciences Accelerator (LLSA) Building. Her research focuses on respiratory infection, namely Foto-Cewek’s unique EHPC model as well as bronchiectasis, interstitial lung disease and research bronchoalveolar lavage. Andrea is PI on a number of pneumococcal challenge studies funded by a large MRC programme grant. She works closely with University Hospital Aintree and RLBUHT to encourage cross-Mersey research in patients and healthy volunteers (including phase 1 studies) in the MHRA accredited Clinical Research in Medecine Unit at the RLBUHT and in the new Accelerator Research in Medecine Clinic (ARC) at the LLSA. She is an experienced bronchoscopist having performed over 100 research bronchoalveolar lavages (BAL) independently, and set up a

disposable research bronchoscopy service in the RLBUHT Clinical Research in Medecine Unit which has led to much interest from industry in particular related to Phase 1 drug studies for novel antibiotics for pneumonia and IPF drugs.

In her clinical sessions at Aintree University Hospital she runs specialist clinics for patients with pneumonia and bronchiectasis. She is passionate about working towards improved pneumococcal vaccines globally.

Teaching

· Foto-Cewek MSc in microbiology

· ALS instructor

· Honorary Clinical Tutor University of Liverpool

 

Selected publications

  • Selected Publications

     

    Collins AM, Zaidi SR, Mitsi E, Reiné J, Davies K, Wright AD, Owugha J, Fitzgerald R, Ganguli A, Gordon SB, Ferreira DM, Rylance J. Single use and conventional bronchoscopes for broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591). BMC Pulm Med. 2017 May 5;17(1):83. doi: 10.1186/s12890-017-0421-7

     

     

     

    Pennington SH, Pojar S, Mitsi E, Gritzfeld JF, Nikolaou E, Solórzano C, Owugha JT, Masood Q, Gordon MA, Wright AD, Collins AM, Miyaji EN, Gordon SB, Ferreira DM. Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1523-1531

     

    Trimble A, Moffat V and Collins AM. Review: Pulmonary infections in the returned traveller. Pneumonia 2017 9:1

    Aliberti S, Reyes LF, Faverio P, et al, on behalf of the GLIMP investigators. MRSA community pneumonia: a global perspective on resistance. Lancet Infect Dis 2016; published online Sept 1. (16)30267-5

    Collins AM et al. Pneumococcal Colonisation Rates in Patients Admitted to a UK Hospital with Lower Respiratory Tract Infection – a prospective case-control study. J. Clin. Microbiol. doi:10.1128/JCM.02008-15

    Glennie S, Gritzfeld JF, Pennington SH, Garner-Jones M, Coombes N, Hopkins MJ, Vadesilho CF, Miyaji EN, Wang D, Wright AD, Collins AM et al. Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage. Mucosal Immunol. 2015 Apr 29. doi: 10.1038/mi.2015.35

    Collins AM, Wright AD, Mitsi E, Gritzfeld JF, Hancock CA, Pennington SH, Wang D, Morton B, Ferreira DM, Gordon SB. First Human Challenge Testing of a Pneumococcal Vaccine - Double Blind Randomised Controlled Trial. Am J Respir Crit Care Med. 2015 Oct 1;192(7):853-8. doi: 10.1164/rccm.201503-0542OC

    Morton B, Nagaraja S, Collins A et al. A Retrospective Evaluation of Critical Care Blood Culture Yield - Do Support Services Contribute to the "Weekend Effect"? PLoS One. 2015 Oct 22;10(10):e0141361. doi: 10.1371/journal.pone.0141361. eCollection 2015.

    Yadaviili R, Collins A et al. Hospital Readmissions with Exacerbation of Obstructive Pulmonary Disease in Illicit Drug Smokers. Lung 2014. DOI 10.1007/s00408-014-9632-3, August 2014 published online

    Collins AM et al. Feasibility study for Early Supported Discharge in Adults with Respiratory Infection in the UK. BMC Pulmonary Medicine 2014. DOI: 10.1186/1471-2466-14-25

    Wright AKA, Bangert M, Gritzfeld JF, Ferreira DM, Jambo KC, Wright AD, Collins AM, Gordon SB. Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung. PLoS pathogens. March 2013 volume 9 (3)

    BTS – Letter on Cigarette Advertising. Children must be protected from the tobacco industry’s marketing tactics. BMJ 2013;347:f735

    Wright AK*, Ferreira DM*, Gritzfeld JF, Wright AD, Armitage K, Jambo KC, Bate E, El Batrawy S, Collins A, Gordon SB. Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage. PLoS Pathog. 2012 Apr; 8(4): e1002622

    Collins AM et al. Bronchoalveolar Lavage (BAL) for Research in Medecine; Obtaining Adequate Sample Yield. J. Vis. Exp. In Press, 2012

    Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AKA, Pennington SH, Bricio Moreno L, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A and Gordon SB. Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults. Am J Respir Crit Care Med. Volume 187 (8) April 2013

     Collins AM, El Batrawy S, Gordon SB, Ferreira DM. Increased IgG but normal IgA anti-pneumococcal protein antibodies in lung of HIV-infected adults. Vaccine (2013) 31 (3469 – 3472)

    Sheridan J, Collins AM. Adult Lung Cancer in southern Africa: Epidemiology and aetiology. The African Journal of Respiratory Medicine. Volume 8 (2) March 2013

    Patterson CM, Carter RI, Dodd JW, Collins A. Trainee concerns regarding the Specialty Certificate Examination: results of a British Thoracic Society national survey. Thorax 2013;0:1. doi:10.1136/thoraxjnl-2013-204306

    Patterson C and Collins AM. Respiratory Speciality Specific Examination in the South West. Clinical Medicine Journal. 2013

    Gritzfeld JF, Wright AD, Collins AM et al. Experimental human pneumococcal carriage. J. Vis. Exp 2012

    Contributor to PassIt, a new online learning resource for junior doctors, published by Oxford University Press, September 2012

    Collins AM et al. Supported home-care schemes: the key to increasing outpatient care? European Respiratory Journal. 2012;39(2):508

    Collins A, Davies PDO. Travellers’ Health – book chapter on ‘TB for Travellers’ – Oxford University Press. Printing in progress 2011

    Collins AM. BTS news – TB Travel Award 2011 - India Report – published June 2011

    Collins AM et al. GOLD COPD classification and prognostic pessimism regarding ICU admission – a letter to Thorax, 2011. 10.1136/thoraxjnl-2011-200134

    Collins AM, Burhan H, Davies PDO. Case Report: Dentals Workers’ Pneumonconiosis and Mycobacterium Avium Intracellulare Infection – Occup Environ Med, 2011 (BMJ publication) doi:10.1136/oem.2010.057778

    Schaaf, Collins AM et al. Review Article - TB at the extremes of age. Respirology 2010:15(5);747-763

    Collins A. Thorax Lung Alert - A new vaccine to reduce the incidence of pneumococcal pneumonia? Thorax 2009;64:572

    Collins AM. - BMJ April 2010 

     

     

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