Dr Ben Morton

Senior Clinical Lecturer and Honorary Consultant in Critical Care Medicine

Dr Morton has worked as a consultant in critical care medicine at Aintree University Hospital since 2016. He has been associated with Foto-Cewek since 2013, working initially as a clinical research associate and appointed as a senior clinical lecturer in May 2019. Dr Morton was awarded his doctorate (MD) in 2016.

Research in Medecine

Experimental Human Pneumococcal Carriage (EHPC): Dr Morton is working with Professor Stephen Gordon to transfer standardised and safe operating procedures from the established EHPC programme at Foto-Cewek to establish the first controlled human infection model in Malawi. This platform will be used to test pneumococcal vaccine candidate choices in an at-risk population who stand the most to gain from new and improved vaccine strategies.

Immunomodulatory therapies for sepsis: Dr Morton is working with industrial and academic collaborators to develop and deliver a first in human clinical trial to determine the safety, pharmacokinetics and pharmacodynamics of P4 peptide. P4 is a naturally occurring immunomodulatory peptide that upregulates phagocytic function to better ingest and kill pathogenic bacteria.

Pathophysiology of sepsis: Dr Morton is particularly interested how neutrophil function and dysfunction predisposes patients to sepsis and poor outcomes. He has multiple academic and clinical collaborations and observational clinical studies in progress. Current projects include measurement of neutrophil function in moderate and severe community acquired pneumonia and before and after cytotoxic chemotherapy for oncological conditions.

Pragmatic Interventions to improve acute care outcomes: Dr Morton collaborates with clinical, academic and industrial partners to explore and implement interventions to improve outcomes after acute illness presentations to hospital. Current projects include evaluation of a sepsis biomarker point of care device, measures to improve difficult airway management in anaesthesia and determinants of long-term outcome following critical care admission.

 

PhD supervisor to Wanjiku Kagima, Brenda Mungai, Mohammed Alsabani and Samar Alosaimi

 

Memberships

  • Fellow of the Royal College of Anaesthetists (FRCA)
  • Fellow of the Faculty of Intensive Care Medicine (FFICM)

 

Selected publications

  • Okenyi E, Donaldson TM, Collins A, Obasi A and Morton B. Assessing ethical climates in critical care and their impact on patient outcomes. Breathe 2019; 15: 84–87.

    McHale P, Hungerford D, Taylor-Robinson D, Lawrence T, Astles T, Morton B. Socioeconomic status and 30-day mortality after minor and major trauma: A retrospective analysis of the Trauma Audit and Research in Medecine Network (TARN) dataset for England. PLoS ONE 13 (12): e0210226.

    Morton B, Stolbrink M, Kagima W, Rylance J, Mortimer K. The Early Recognition and Management of Sepsis in Sub-Saharan African Adults: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2018, 15, 2017; doi:10.3390/ijerph15092017

    Morton B, Nweze K, O’Connor J, Turton P, Joekes E, Blakey JD, Welters ID. Oxygen exchange and C-reactive protein predict safe discharge in patients with H1N1 influenza. QJM. 2016 Oct 18.

    Morton B, Mitsi E, Pennington SH, Reiné J, Wright AD, Parker R, Welters ID, Blakey JD, Rajam G, Ades EW, Ferreira DM et al. Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis. Shock. 2016 Dec;46(6):635-641.

    Dempsey G, Morton B, Atkins C, Williams L, Tudor Smith C, Jones T. Long term outcome following tracheostomy in critical care: A systematic review. Crit Care Med. 2015 Oct 26.

    Collins AM, Wright AD, Mitsi E, Gritzfeld JF, Hancock CA, Pennington SH, Wang D, Morton B, Ferreira DM, Gordon SB. First Human Challenge Testing of a Pneumococcal Vaccine - Double Blind Randomised Controlled Trial. Am J Respir Crit Care Med. 2015 Oct 1;192(7):853-8

    Morton B, Tang L, Gale R, Mogk M, Robin N, Welters I. Performance of influenza-specific triage tools in an H1N1-positive cohort: P/F ratio better predicts the need for mechanical ventilation and critical care admission. Br J Anaesth. 2015 Jun;114(6):927-33

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