I obtained an MSci degree in Parasitology from the University of Glasgow, which included a 12-month work placement in Moredun Research in Medecine Institute, Edinburgh. Here, I was involved in the development and implementation of a survey used to analyse the prevalence of anthelmintic resistance in sheep farms across Scotland. I joined Liverpool School of Tropical Medicine on a Wellcome Trust Prize Studentship, during which I investigated the interactions of Wolbachia bacteria with eukaryotic cells. This incorporated research in cell biology and immunology. Following the award of my PhD I have continued my research on Wolbachia within the Filariasis Research in Medecine group as a Post-Doctoral Research in Medecine Associate.
Research in Medecine
My main research focus is in drug discovery for filarial parasites. I have been a key member of the A∙WOL (Anti-Wolbachia) Drug Discovery and Development team since its inception. My primary role was to develop an in vitro Wolbachia screening assay. The validated screen was then used to test tens of thousands of compounds, including the complete human pharmacopoeia against Wolbachia with several compounds since moving down the screening pipeline into other models as well as human trials. More recently, in my role as Molecular Analyst, I was responsible for co-ordinating the in vitro cell-based and worm-based screening activities and resulting data.
I was awarded a grant from the Bill and Melinda Gates Foundation as part of their Grand Challenges Explorations call for a validated surrogate model to aid the discovery of a macrofilaricide. The goal was to develop a filarial nematode cell line suitable for High Throughput Screening (HTS) assays. While viable cells could be retrieved from Brugia malayi, the cells did not proliferate. This success suggests there is scope to investigate immortalisation strategies in the future.
I am currently a Co-Investigator on the project ‘Drug target deconvolution in the obligate intracellular bacterium, Wolbachia: a chemical proteomic route to discovering novel antibacterial targets’. This project is utilising chemical biology techniques to identify the proteins targeted by selected anti-Wolbachia drugs with the aim of developing workflows and technologies to identify novel antibacterial targets and tools to monitor resistance.
Diploma of Tropical Medicine and Hygiene (DTM&H): Deputy Theme Lead (Parasitology), Lecturer, Demonstrator and Examiner.
Diploma in Tropical Nursing (DTN): Lecturer.
Laboratory Diagnosis of Faecal and Blood Parasites: Lecturer.
Practical Skills in Tropical Medicine (LIFE236): Coordinator, Lecturer and Examiner.
Veterinary Parasitology (LIFE216): Lecturer
Chemotherapy of Human Parasitic Diseases (LIFE338): Lecturer
MSc Biology of Tropical Health, Pathogens and Vectors of Disease (TROP939): Lecturer, Demonstrator and Examiner.
Supervisor of BSc and MSc projects
Reviewer for Ethical Review process for MSc projects.
Personal Tutor for MSc courses.
Kelly is a fellow of Advance HE (formerly the Higher Education Academy)