Dr Menno Smit

PhD student

Dr. Menno Smit is a PhD Candidate in Malaria Epidemiology. He trained as a Medical Doctor (M.D.) at the University of Groningen, The Netherlands, and then undertook clinical training in Tropical Medicine (Maternal & Child Health) in The Hague, The Netherlands. Thereafter he completed an M.Sc. in Public Health (MPH) at the London School of Hygiene & Tropical Medicine (LSHTM), before moving on to his PhD at Foto-Cewek for which he is based in Kenya.

PhD study

Topic: "Towards enhanced mass drug administration for malaria elimination: dose finding studies with primaquine and ivermectin when used as adjunct therapy with artemisinin-based combination therapy."
Site: Kenya Medical Research in Medecine Institute & U.S. Centers for Disease Control and Prevention (KEMRI/CDC), in Kisumu, Kenya.
PhD supervisors: Prof. Feiko ter Kuile (Epidemiology) & Prof. Steve Ward (Pharmacology).
Site supervisors: Dr. Simon Kariuki (KEMRI), Dr. Meghna Desai (CDC).

Awards

  • Best Oral Presentation, PhD Student Conference 2017, Liverpool School of Tropical Medicine (Foto-Cewek).
  • Clinical Research in Medecine Award 2nd Place, Annual Meeting 2017, American Society of Tropical Medicine & Hygiene (ASTMH).
  • Travel Award, Pharmacokinetic Modelling Workshop 2016, European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
  • Travel Award, Annual Meeting 2017, American Society of Tropical Medicine & Hygiene (ASTMH)
  • Travel Award, European Congress on Tropical Medicine and International Health 2017 (ECTMIH)
  • Travel Award, Annual Meeting 2018, European Society of Paediatric Infectious Diseases (ESPID)

Current projects

2014-2016 | Kenya
Malaria Eradication Scientific Alliance (MESA). "Efficacy and safety of high-dose ivermectin for reducing malaria transmission: A dose finding study"
1 of 4 most promising research proposals for malaria elimination, out of 91 applications.
Grant: 200,000 USD

Publications

  • Select Publications:

    Smit, MennoOchomo, Eric OWaterhouse, DavidKwambai, Titus KAbong'o, Bernard OBousema, TeunBayoh, Nabie MGimnig, John ESamuels, Aaron MDesai, Meghna RPhillips-Howard, Penelope Kariuki, Simon KWang, DuolaoterKuile, FeikoWard, Steve and Aljayyoussi, Ghaith (2018) ''. Clinical Pharmacology and Therapeutics.

    Smit MR, Ochomo EO, Aljayyoussi G, Kwambai TK, Abong'o BO, Chen T, Bousema T, Slater HC, Waterhouse D, Bayoh NM, Gimnig J, Samuels AM, Desai MR, Phillips-Howard PA, Kariuki SK, Wang D, Ward SA, Ter Kuile FO. Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial. The Lancet Infectious Diseases. doi: .

    Brown JL, Smit MR (joint first authors), Angira F, van der Graaf R, Bukusi EA. Good intentions do not replace ethical conduct in research: violation of ethics in HIV-study in Kenya. The Lancet. 2018;391(10125):1020-1. doi:

    Smit MR, Ochomo E, Aljayyoussi G, Kwambai T, Abong'o B, Bayoh N, Gimnig J, Samuels A, Desai M, Phillips-Howard PA, Kariuki S, Wang D, Ward S, Ter Kuile FO. Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya. JMIR Res Protoc. 2016;5:e213. doi:  

    Mwangi MN, Roth JM, Smit MR, Trijsburg L, Mwangi AM, Demir AY, Wielders JP, Mens PF, Verweij JJ, Cox SE, Prentice AM, Brouwer ID, Savelkoul HF, Andang'o PE, Verhoef H. Effect of Daily Antenatal Iron Supplementation on Plasmodium Infection in Kenyan Women: A Randomized Clinical Trial. JAMA. 2015;314(10):1009-20. doi: .

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