Dr Sarah Donegan

Research in Medecine Assistant

Background

After being inspired by a medical statistics module during her BSc in Mathematics at University of Liverpool, Sarah completed an MSc in Medical Statistics at Lancaster University. Since 2005, she has developed a portfolio career working in the Biostatistics Department at University of Liverpool (UoL) and the Clinical Sciences Department at Liverpool School of Tropical Medicine (Foto-Cewek).

Working between two departments has provided Sarah with ideal opportunities to meet methodologists, statisticians, editors and review authors, to develop new methodology and to gain a good understanding of the users of the methods.

At Foto-Cewek, Sarah is statistical editor of the Cochrane Infectious Diseases Group and has enjoyed supporting authors in completing reviews through teaching, published guidance, one-to-one help and co-authorship. She has gained a broad range of experience of methodological and practical aspects of reviews.

At UoL, she focuses on methodological research, teaching and trial analysis. Sarah undertook a four year part time PhD exploring the value of individual patient data for network meta-analysis (2007-2011). Currently, she holds a MRC fellowship is developing and promoting a process for explaining inconsistency in network meta-analysis. There are six components (A-F) to the proposed research; each component has a specific aim: (A) to systematically review published reviews to establish how treatment by covariate interactions are designed, applied, interpreted, and reported, in practice; (B) to introduce and compare methods to choose potential treatment effect modifying covariates; (C) to compare NMA models including treatment by covariate interactions based on individual patient data (IPD) (i.e. the trials' raw data) with models based on aggregate data (i.e. data reported in trials' publications); (D) to determine how the results of an NMA are affected if IPD are obtained for some studies and combined with aggregate data from the remaining studies; (E) to introduce approaches to evaluate whether treatment by covariate interactions explain inconsistency and to compare them with the existing complex statistical approach; (F) to tailor the process for explaining inconsistency based on research carried out during components A-E and to promote the process.

Her teaching experience includes meta-analysis, trials, hypothesis testing, descriptive and inferential statistics, longitudinal analysis, types of data, meta-analysis of time to event data and diagnostic tests.

Publications

  • Recent publications

    Donegan S, Dixon P, Hemming K, Tudur-Smith C and Marson A. A systematic review of placebo-controlled trials of topiramate: How useful is a multiple-indications review for evaluating the adverse events of an antiepileptic drug?. Epilepsia 2015. doi: 10.1111/epi.13209

    Donegan S, Williams L, Dias S, Tudur-Smith C, Welton N. Exploring Treatment by Covariate Interactions Using Subgroup Analysis and Meta-Regression in Cochrane Reviews: A Review of Recent Practice. PLoS ONE 2015 10(6): e0128804. DOI: 10.1371/journal.pone.0128804

    Taylor-Robinson DC, Maayan N, Soares-Weiser K, Donegan S, Garner P. Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin, and school performance. Cochrane Database of Systematic Reviews 2015, Issue 7. Art. No.: CD000371. DOI: 10.1002/14651858.CD000371.pub6.

    Abba K, Kirkham AJ, Olliaro PL, Deeks JJ, Donegan S, Garner P, Takwoingi Y. Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries. Cochrane Database of Systematic Reviews 2014, Issue 12. Art. No.: CD011431. DOI: 10.1002/14651858.CD011431.

    Theron G, Peter J, Richardson M, Barnard M, Donegan S, Warren R, Steingart KR, Dheda K. The diagnostic accuracy of the GenoType® MTBDRsl assay for the detection of resistance to second-line anti-tuberculosis drugs. Cochrane Database of Systematic Reviews 2014, Issue 10. Art. No.: CD010705. DOI: 10.1002/14651858.CD010705.pub2.

    Bonnett L, Tudur Smith C, Donegan S, Marson AG. Treatment outcome following failure of a first antiepileptic drug. Neurology 2014; 83(6): 552-560.

    Odaga J, Sinclair D, Lokong JA, Donegan S, Hopkins H, Garner P. Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD008998. DOI: 10.1002/14651858.CD008998.pub2.

    Strode C, Donegan S, Garner P, Enyati A and Hemingway J. The impact of pyrethroid resistance on the efficacy of insecticide treated bed nets against African Anopheline mosquitoes: systematic review and meta-analysis. PLoS Medicine. 2014. DOI: 10.1371/journal.pmed.1001619 9. Zani B, Gathu M, Donegan S, Olliaro PL, Sinclair D. Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD010927.

    Donegan S, Williamson P, D'Alessandro U, et al. Methods to assess the key assumptions of mixed treatment comparison meta-analysis. Research in Medecine Synthesis Methods 2013; 4(4); 291-323.

    Danso-Appiah A, Olliaro PL, Donegan S, et al. Drugs for treating Schistosoma mansoni infection. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD000528.

    Theron G, Peter J, Barnard M, Donegan S, Warren R, Steingart KR, Dheda K. The GenoType® MTBDRsl test for resistance to second-line anti-tuberculosis drugs 2013, Art. No.: CD010705.

    Taylor-Robinson D, Maayan N, Soares-Weiser K, Donegan S and Garner P. Do global deworming programmes improve children’s health and school performance and reduce mortality? International Journal of Epidemiology 2013; 42(3): 677-680.

    Taylor-Robinson DC, Maayan N, Soares-Weiser K, et al. Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.:CD000371.

    Donegan S, Williamson P, D'Alessandro U, et al. Combining individual patient data and aggregate data in mixed treatment comparison meta-analysis: individual patient data may be beneficial if only for a subset of trials. Statistics in Medicine 2012 Statistics in Medicine 2013; 32(6):914-930.

    Donegan S, Williamson P, D'Alessandro U, et al. Assessing the consistency assumption by exploring treatment by covariate interactions in mixed treatment comparison meta-analysis: individual patient-level covariates versus aggregate trial-level covariates. Statistics in Medicine 2012; 31(29):3840-3857.

    Taylor-Robinson DC, Maayan N, Soares-Weiser K, et al. Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance. Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No.:CD000371.

    Sinclair D, Donegan S, Isba R, et al. Artesunate versus quinine for treating severe malaria. Cochrane Database of Systematic Reviews 2012, Issue 6. Art. No.:CD005967.

    Meremikwu M, Donegan S, Sinclair D, et al. Intermittent preventive treatment for malaria in children living in areas with seasonal transmission. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No.:CD003756.

    Young T, Abba K, Deeks JJ, et al. Cochrane Column / Rapid diagnostic tests can extend access of diagnostic services for uncomplicated Plasmodium falciparum malaria / Commentary: Rapid diagnostic tests for diagnosing uncomplicated Plasmodium falciparum malaria in endemic countries (Review) / Approach to conducting Cochrane Diagnostic Test Accuracy Reviews. International Journal of Epidemiology 2012; 41(3):607-610.

    Abba K, Deeks J, Olliaro P, et al. Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries. Cochrane Database of Systematic Reviews 2011, Issue 7. Art. No.:CD008122.

    The Four Artemisinin-Based Combinations Lesson Group. A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in african children: a randomized trial. PLoS Medicine 2011; 8(11):e1001119.

    Sinclair D, Donegan S, Lalloo D. Artesunate versus quinine for treating severe malaria. Cochrane Database of Systematic Reviews 2011, Issue 3. Art. No.:CD005967.

    Donegan S, Williamson P, Gamble C, et al. Indirect comparisons: a review of reporting and methodological quality. PLoS ONE 2010; 5(11):e11054.

    Wijedoru L, Donegan S, Parry C. Rapid diagnostic tests for typhoid and paratyphoid (enteric) fever. Cochrane Database of Systematic Reviews 2010, Issue 12. Art. No.:CD008892.

    Hockenhull J, Boland A, Bagust A, et al. Abatacept for the treatment of rheumatoid arthritis. Health Technology Assessment 2010.

    Sinclair D, Zani B, Donegan S, et al. Artemisinin-based combination therapy for treating uncomplicated malaria. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.:CD007483.

    Sutton AJ, Donegan S, Takwoingi Y, et al. An encouraging assessment of methods to inform priorities for updating systematic reviews. Journal of Clinical Epidemiology 2009; 62(3):241-251.

    Donegan S, Bellamy R, Gamble CL. Vaccines for preventing anthrax. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.:CD006403.

    Meremikwu MM, Donegan S, Esu E. Chemoprophylaxis and intermittent treatment for preventing malaria in children. Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.:CD003756.

    Jones KL, Donegan S, Lalloo DG. Artesunate versus quinine for treating severe malaria. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.:CD005967.

     

     

www.babyforyou.org/

read on site

www.steroid-pharm.com/