Dr Simon Jochems

Post Doctoral Research in Medecine Assistant

Simon obtained a MSc in Biomedical Sciences from the University of Utrecht (Netherlands) in 2011. During this, he worked as an intern in the labs of Jos Van Strijp (Medical Microbiology, UMC Utrecht) and Guido Silvestri (Emory University, Atlanta, US). He then did his PhD at Institut Pasteur, Paris, France, in the team of Dr. Müller-Trutwin, part of the laboratory of Prof. Françoise Barré-Sinoussi. His PhD research concerned the molecular mechanisms underlying the resolution of immune activation after simian immunodeficiency virus (SIV) infection in its natural host: African green monkeys. Specifically, he investigated the role of DNA methylation in immunological and virological control by characterizing the African green monkey methylome during SIV infection. He compared these data to a model of pathogenic SIV infection and integrated them with genome-wide transcriptomic analyses to gain insight in virus-host interplay. In addition, he investigated differences in Type I Interferon responses and plasmacytoid dendritic cell (pDC) function and phenotype between natural hosts of SIV and progressive SIV infections. 

Research in Medecine
Simon is interested in why certain groups of individuals, such as the elderly, influenza-infected individuals, asthmatics, smokers and HIV-infected individuals display increased susceptibility to pneumococcal disease. These risk groups have an inflammatory milieu in the respiratory tract in common, which could underlie their susceptibility to pneumococcus. While an inflammatory response is required for pneumococcal control, previous research has identified associations between excessive inflammation and pneumococcal disease progression. His main research question is therefore whether an altered inflammatory environment predisposes to pneumococcal disease.

Teaching
Simon has co-supervised a M.Sc student during his PhD in Paris for a two-month period.

Students (Names of students you supervise)

Vincent Guiraud - 2014

Current Projects and Grants

Effect of Live Attenuated and Inactivated Influenza vaccines on Experimental Human Pneumococcal Carriage – Bill and Melinda Gates Foundation grant to Dr. Daniela Ferreira

Selected publications

  • Recent Publications (2012-2014)

    Efficient SIV sensing and infection in plasmacytoid dendritic cells of African green monkeys despite low CD4 and CCR5 expression. Jochems SP, Jacquelin B, Chauveau L, Huot N, Petitjean G, Lepelley A, Liovat AS, Ploquin MJ, Cartwright EK, Bosinger SE, Silvestri G, Barré-Sinoussi F, Lebon P, Schwartz O, Müller-Trutwin MC. J. Virol. J Virol. 2015 Jul 1;89(13):6918-27. doi: 10.1128/JVI.00332-15.
    Modulation of Type I interferon-associated viral sensing during acute SIV infection in African green monkeys. Jochems SP, Petitjean G, Kunkel D,Liovat AS, Ploquin MJ, Barré-Sinoussi F, Lebon P, Jacquelin B, Müller-Trutwin MC. J Virol. 2015 Jan 1;89(1):751-62. doi: 10.1128/JVI.02430-14.
    Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or not with Interferon-Alpha during Primary SIVagm Infection. Jacquelin B, Petitjean G, Kunkel D, Liovat AS, Jochems SP, Rogers K, Ploquin M, Madec Y, Barré-Sinoussi F, Dereuddre-Bosquet N, Lebon P, Le Grand R, Villinger F, Müller-Trutwin M. Plos Pathogens. 2014. DOI: 10.1371/journal.ppat.1004241
    Intact type I Interferon production and IRF7 function in sooty mangabeys. Bosinger SE, Johnson ZP, Folkner KA, Patel N, Hashempour T, Jochems SP, Del Rio Estrada PM, Paiardini M, Lin R,  Vanderford TH, Hiscott J, Silvestri G. PLoS Pathog. 2013;9(8):e1003597.  oi:10.1371/journal.ppat.1003597.
    Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239. Bosinger SE, Jochems SP, Folkner KA, Hayes TL, Klatt NR, Silvestri G. J Virol. 2013 Jan;87(1):433-43. doi: 10.1128/JVI.01746-12.
    Innate immunity in the control of HIV/AIDS: recent advances and open questions. Ploquin MJ, Jacquelin B, Jochems SP, Barré-Sinoussi F, Müller-Trutwin MC. AIDS. 2012 Jun 19;26(10):1269-79. doi: 10.1097/QAD.0b013e328353e46b. Review.

    Book Chapter

    Simian immunodeficiency virus infection in African green monkeys: a model of protection against AIDS.Jochems SP, Jacquelin B, Ploquin M, Müller-Trutwin M. Encyclopedia of AIDS, Springer. Book chapter. Oct 2014. Doi: 10.1007/978-1-4614-9610-6_203-1

     

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