Dr Luc Salako Djogbenou

Honorary Research in Medecine Fellow

Senior Lecturer in Universty of Abomey-Calavi, Benin

I have a PhD in Medical Entomology from University of Montpellier, France.  From 2010 to 2012,  I conducted postdoctoral training at the Liverpool School of Tropical Medicine, UK.  From 2010, I  started establishing laboratory in University of Abomey-Calavi in Benin and current an Associate Professor, head of Health–Environment Department and head of the Laboratory of Vector Borne Infectious Diseases in Institut Régional de Santé Publique/University of Abomey-Calavi in Benin.  

My main research interest activities regroup several aspects related to the control of mosquito vectors of human disease such as Malaria, Lymphatic Filariasis and Dengue. Particularly my research is focused on the understanding of the biology, genetics and genomics of mosquitoes vectors. For several years I worked on the main causes and consequences of insecticide resistance mechanisms on the biology of Anopheles gambiae in West Africa. I primary work on the apparition and the role of acetycholinesterase gene duplication in Anopheles gambiae in West Africa. My work involves five West Africa countries namely Nigeria, Burkina Faso, Togo, Côte d’Ivoire and Ghana. My other research interests lies on public health outreach and also investigate how social practices relating to pesticide use by populations in Africa impact sustainable control of Anopheles funestus and Anopheles gambiae s.s. I am currently conducting research to determine the impact of the genetic profile of both vector and parasite on the malaria transmission.  

I am currently the principal investigator of a Wellcome Trust funded project (under Foto-Cewek sponsorship) on “the impact of insecticide resistance and exposure on Plasmodium infection level and prevalence in the malaria vector Anopheles gambiae” (WT 109917/Z/15/Z grant 02/2016-02/2021). I am also the Co-PI for GCRF Foundation grant (MR/P02520X/1: 2017-2019) and for the DFG Foundation grant (COMAL: 2018-2020). I have previously held grants with the Wellcome Trust, IRD, WHO/TDR, IRDC, AIEA, ANR France, and the MIM. Through these grants, I trained 10 MSc students, 3 PhD students, 1 postdoctoral fellows in the last 10 years in my laboratory in Benin. Since 2012, I am a member of the Benin MNCP’s Technical Expert Group on Malaria Vector Control and insecticide resistance management. 

Research in Medecine focus:

Lesson Malaria Parasites-vector interactions that define transmission in Africa

Use of variety of genomic, transcriptomic and proteomic approaches to identify and validate insecticide resistance associated loci.

Teaching:

I teach on the Masters programmes in Applied Biochemistry and Molecular Biology and Applied Entomology at University of Abomey-Calavi.

2010- Member of The American Society of Tropical Medicine and Hygiene (ASTMH)

2010-Member of the Benin MNCP’s Technical Expert Group on Malaria Vector Control and insecticide resistance management.

2011-Member West & Central Africa Community of Practice in Ecosystem Approaches to Health.

Selected publications

  • Selected publications 

    2016

    Assogba, B. S., P. Milesi, L. S. Djogbenou, A. Berthomieu, P. Makoundou, L. S. Baba-Moussa, A. S. Fiston-Lavier, K. Belkhir, P. Labbe, and M. Weill. 2016. The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous Duplications. PLoS Biol 14: e2000618.

    Basu, N., P. A. Ayelo, L. S. Djogbenou, M. Kedote, H. Lawin, H. Tohon, E. O. Oloruntoba, N. A. Adebisi, D. Cazabon, J. Fobil, T. Robins, and B. Fayomi. 2016. Occupational and Environmental Health Risks Associated with Informal Sector Activities-Selected Case Studies from West Africa. New Solut 26: 253-270.

    Alout, H., R. K. Dabire, L. S. Djogbenou, L. Abate, V. Corbel, F. Chandre, and A. Cohuet. 2016. Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae. Sci Rep. 6: 29755.

    Luc S. Djogbenou, Assogba Benoit, Djossou Laurette & Michel Makoutodé. 2016. Indirect Evidence that Agricultural Pesticides Select for Insecticide Resistance in the Malaria Vector Anopheles gambaie. Journal of Vector Ecology 41:34-40 . 

    2015
    Benoît S. Assogba, Luc S. Djogbénou, Pascal Milesi, Arnaud Berthomieu, Julie Perez, Diego Ayala, Fabrice Chandre, Michel Makoutodé, Pierrick Labbé, Mylène Weill. 2015. An Ace-1 gene duplication resorbs the fitness cost associated with resistance in malaria mosquitoes. Report Scientific, Sci Rep. 2015 Oct 5;5:14529 

    2014
    Yahouedo, G. A., L. Djogbénou, J. Saizonou, B. S. Assogba, M. Makoutode, J. R. Gilles, H. Maiga, K. Mouline, B. K. Soukou, and F. Simard. 2014. Effect of three larval diets on larval development and male sexual performance of Anopheles gambiae s.s. Acta tropica 132 Suppl: S96-101.

    Lees, R. S., B. Knols, R. Bellini, M. Q. Benedict, A. Bheecarry, H. C. Bossin, D. D. Chadee, J. Charlwood, R. K. Dabire, L. Djogbenou, A. Egyir-Yawson, R. Gato, L. C. Gouagna, M. M. Hassan, S. A. Khan, L. L. Koekemoer, G. Lemperiere, N. C. Manoukis, R. Mozuraitis, R. J. Pitts, F. Simard, and J. R. Gilles. 2014. Review: Improving our knowledge of male mosquito biology in relation to genetic control programmes. Acta tropica 132 Suppl: S2-11.

    Assogba, B. S., L. Djogbenou, J. Saizonou, A. Diabate, R. K. Dabire, N. Moiroux, J. R. Gilles, M. Makoutode, and T. Baldet. 2014. Characterization of swarming and mating behaviour between Anopheles coluzzii and Anopheles melas in a sympatry area of Benin. Acta tropica 132 Suppl: S53-63.

    Assogba, B. S., L. S. Djogbenou, J. Saizonou, P. Milesi, L. Djossou, I. Djegbe, W. A. Oumbouke, F. Chandre, L. Baba-Moussa, M. Weill, and M. Makoutode. 2014. Phenotypic effects of concomitant insensitive acetylcholinesterase ( ace-1 R ) and knockdown resistance ( kdr R ) in Anopheles gambiae : a hindrance for insecticide resistance management for malaria vector control. Parasites & vectors 7: 548.

    Alout, H., B. Yameogo, L. S. Djogbenou, F. Chandre, R. K. Dabire, V. Corbel, and A. Cohuet. 2014. Interplay between Plasmodium infection and resistance to insecticides in vector mosquitoes. The Journal of infectious diseases 210: 1464-1470.

    Alout, H., I. Djegbe, F. Chandre, L. S. Djogbenou, R. K. Dabire, V. Corbel, and A. Cohuet. 2014. Insecticide exposure impacts vector-parasite interactions in insecticide-resistant malaria vectors. Proceedings. Biological sciences / The Royal Society 281. 

    2013
    Claude Ahouangninou, T. M., Françoise Assogba-Komlan, Serge Simon, Luc Djogbénou, Ibrahim Siddick, Cédric Pennetier, Vincent Corbel, Benjamin Fayomi. 2013. Using Aedes aegypti larvae to Assess Pesticide Contamination of Soil, Groundwater and Vegetables. British Biotechnology Journal 3: 143-157.

    Alout, H., N. T. Ndam, M. M. Sandeu, I. Djegbe, F. Chandre, R. K. Dabire, L. S. Djogbenou, V. Corbel, and A. Cohuet. 2013. Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates. PloS one 8: e63849.

    2012
    Dabiré K. R., A. Diabaté, M. Namountougou, L. Djogbenou, C. Wondji, F. Chandre, F. Simard, J-B. Ouédraogo, T. Martin, M. Weill, T. Baldet. 2012. Trends in Insecticide Resistance in Natural Populations of Malaria Vectors in Burkina Faso, West Africa: 10 Years Surveys. Insecticides - Pest Engineering, 02/2012; , ISBN: 978-953-307-895-3

    Alout, H., P. Labbe, A. Berthomieu, L. Djogbenou, J. P. Leonetti, P. Fort, and M. Weill. 2012. Novel AChE inhibitors for sustainable insecticide resistance management. PloS one 7: e47125.

    Sahabi Bio-Bangana, C. H., Razaki Ossé, Patrick Edorh, Luc Djogbénou, Claude C.A. Ahouangninou, Michel Boko, Martin Akogbéto. 2012. Characterization of mosquito fauna in the sanitary district Ouidah-Kpomasse-Tori Bossito in Benin. International Journal of Biosciences 2 31-39. 

    2011
    Pierrick Labbé, Haoues Alout, Luc Djogbénou, Nicole Pasteur, Mylène Weill. 2011. Evolution of Resistance to Insecticide in Disease Vectors. Genetics and Evolution of Infectious Disease, pages 363-409; , ISBN: 9780123848901

    Yadouleton, A., T. Martin, G. Padonou, F. Chandre, A. Asidi, L. Djogbenou, R. Dabire, R. Aikpon, M. Boko, I. Glitho, and M. Akogbeto. 2011. Cotton pest management practices and the selection of pyrethroid resistance in Anopheles gambiae population in northern Benin. Parasites & vectors 4: 60.
    Djogbénou, L., N. Pasteur, M. Akogbeto, M. Weill, and F. Chandre. 2011. Insecticide resistance in the Anopheles gambiae complex in Benin: a nationwide survey. Medical and veterinary entomology 25: 256-267. 

    2010
    Djogbénou, L., N. Pasteur, S. Bio-Bangana, T. Baldet, S. R. Irish, M. Akogbeto, M. Weill, and F. Chandre. 2010. Malaria vectors in the Republic of Benin: distribution of species and molecular forms of the Anopheles gambiae complex. Acta tropica 114: 116-122.

    Fabrice Chandre, Roch K Dabire, Jean-Marc Hougard, Luc S Djogbenou, Seth R Irish, Mark Rowland, Raphael N'guessan. 2010. Field efficacy of pyrethroid treated plastic sheeting (durable lining) in combination with long lasting insecticidal nets against malaria vectors. Parasites & Vectors 08/2010; 3(1):65. DOI:10.1186/1756-3305-3-65 ·

    Djogbénou, L., V. Noel, and P. Agnew. 2010. Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation. Malaria journal 9: 12.

    Chandre, F., R. K. Dabire, J. M. Hougard, L. S. Djogbenou, S. R. Irish, M. Rowland, and R. N'Guessan. 2010. Field efficacy of pyrethroid treated plastic sheeting (durable lining) in combination with long lasting insecticidal nets against malaria vectors. Parasites & vectors 3: 65.

    Djogbénou, L., V. Noel, and P. Agnew. 2010. Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation. Malaria journal 9: 12.

    2009
    Dabire, K. R., A. Diabate, M. Namontougou, L. Djogbenou, P. Kengne, F. Simard, C. Bass, and T. Baldet. 2009. Distribution of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae s.l. populations from Burkina Faso (West Africa). Tropical medicine & international health : TM & IH 14: 396-403.

    Djogbénou, L., P. Labbe, F. Chandre, N. Pasteur, and M. Weill. 2009. Ace-1 duplication in Anopheles gambiae: a challenge for malaria control. Malaria journal 8: 70.

    Djogbénou, L. 2009. [Vector control methods against malaria and vector resistance to insecticides in Africa]. Medecine tropicale : revue du Corps de sante colonial 69: 160-164. 

    2008
    Alout, H., L. Djogbenou, C. Berticat, F. Chandre, and M. Weill. 2008. Comparison of Anopheles gambiae and Culex pipiens acetycholinesterase 1 biochemical properties. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 150: 271-277.

     

    Djogbénou, L., R. Dabire, A. Diabate, P. Kengne, M. Akogbeto, J. M. Hougard, and F. Chandre. 2008. Identification and geographic distribution of the ACE-1R mutation in the malaria vector Anopheles gambiae in south-western Burkina Faso, West Africa. The American journal of tropical medicine and hygiene 78: 298-302.

    Djogbénou, L., F. Chandre, A. Berthomieu, R. Dabire, A. Koffi, H. Alout, and M. Weill. 2008. Evidence of introgression of the ace-1(R) mutation and of the ace-1 duplication in West African Anopheles gambiae s. s. PloS one 3: e2172.

    Djogbénou, L., M. Akogbeto, and F. Chandre. 2008. Presence of insensitive acetylcholinesterase in wild populations of Culex pipiens quinquefasciatus from Benin. Acta tropica 107: 272-274.

    Dabire, K. R., A. Diabate, L. Djogbenou, A. Ouari, R. N'Guessan, J. B. Ouedraogo, J. M. Hougard, F. Chandre, and T. Baldet. 2008. Dynamics of multiple insecticide resistance in the malaria vector Anopheles gambiae in a rice growing area in South-Western Burkina Faso. Malaria journal 7: 188. 

    2007
    Djogbénou, L., M. Weill, J. M. Hougard, M. Raymond, M. Akogbeto, and F. Chandre. 2007. Characterization of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae (Diptera: Culicidae): resistance levels and dominance. Journal of medical entomology 44: 805-810.

    Corbel, V., R. N'Guessan, C. Brengues, F. Chandre, L. Djogbenou, T. Martin, M. Akogbeto, J. M. Hougard, and M. Rowland. 2007. Multiple insecticide resistance mechanisms in Anopheles gambiae and Culex quinquefasciatus from Benin, West Africa. Acta tropica 101: 207-216.

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