Ms Rachel Clare

Research in Medecine Assistant and PhD Student

Areas of interest

Wolbachia bacteria of filarial nematodes as an anti-filarial drug target for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness).

Background

Rachel Clare graduated in 2007 with a Master degree in Biology focusing on insect immunity in her Masters year. She carried out a 3 month field based project in Madagascar on the role water holes play in disease transmission between various species during the dry season. In 2007 she joined the pharmaceutical industry as a protein scientist focusing on cancer research. Rachel joined Foto-Cewek in 2010 as a Research in Medecine Assistant and is currently working on identifying new drugs for Lymphatic filariasis and Onchoceriasis. 

She is currently also undertaking a part-time PhD within the same subject. 

Research in Medecine

Endosymbiotic bacteria, Wolbachia, are present in most species of filarial nematodes, including those that cause Lymphatic filariasis and Onchocerciasis in humans. These bacteria are essential for parasite survival and fecundity and are thus seen as an important drug target for filarial chemotherapy. High Throughput Screening is being carried out to identify new drugs targeting Wolbachia using an in-house screening assay.

As part of her PhD role she is involved in assay development and screening in collaboration with AstraZeneca.

Publications

  • Selected publications

    Clare, R. H., D. A. Cook, et al. (2015). "Development and Validation of a High-Throughput Anti-Wolbachia Whole-Cell Screen: A Route to Macrofilaricidal Drugs against Onchocerciasis and Lymphatic Filariasis." J Biomol Screen 20 (1): 64-69

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