Professor Stephen Gordon

Director MLW

Areas of interest

Susceptibility to lung infection, pneumococcal disease and inhaled vaccines.  Household air pollution and lung diseases.  Capacity building in medical research in Africa.

Background

Stephen Gordon was educated at the University of Cambridge and trained in General Medicine in Oxford, Zambia and Belfast.  He specialised in Respiratory Medicine in Sheffield (Clinical Lecturer) and Malawi (2 Wellcome Trust Fellowships).

Stephen Gordon joined the Liverpool School of Tropical Medicine in 2005, with a remit to establish laboratory and clinical research on susceptibility to pulmonary infections.  Stephen's research in Sheffield and Malawi had focused on susceptibility to respiratory infection and in particular, on the effect of HIV infection on susceptibility to pneumococcal disease.  The work demonstrated that pulmonary mucosal defence was regulated differently than systemic defence against infection, and could be perturbed by environmental exposures including indoor air pollution.

The Respiratory group at Foto-Cewek has themes of research targeting vaccine discovery and testing, pathogenesis and the treatment of pneumococcal disease, using human samples from both healthy volunteers and patients.  We collaborate closely with hospital colleagues and have developed an Experimental Human Pneumococal Carriage (EHPC) model in which healthy volunteers are challenged with pneumococci in order to study the immunological correlates of carriage, protection and clearance.  This work has been substantially supported by NIHR, the Bill and Melinda Gates Foundation and the MRC.  Current funding includes an MRC Programme grant (2015-2020) and a BMGF grant to study the effect of live attenuated influenza vaccine on EHPC.

We have also developed our studies of the effect of biomass fuel smoke on defence against infection.  In particular, jointly with Dr Kevin Mortimer, Stephen now leads a large DBRCT in Malawi to determine the effect of an advanced cook stove in prevention of pneumonia by reduction of household air pollution.  This study cohort also supports an MRC Partnership grant (BREATHE Africa) to develop collaborations in Household Air Pollution (HAP) research and a linked study of Adult Lung Health.

Stephen holds an Honorary Consultant Contract in General Medicine in the Royal Liverpool University Hospital and University Hospital Aintree.  He combines Respiratory and General Medicine with research and teaching.

Students

9 postgraduate students

Dr Dan Wootton, Dr Andrea Collins, Ms Jenna Gritzfeld, Dr Stephen Aston, Dr Hannah Jary, Mr Shaun Pennington, Ms Suzy Gore, Mr Abdullah Aljurayyan, Dr Ben Morton.

Selected publications

  • Selected Publications

     Hyams C, Tam JC, Brown JS, Gordon SB. PLoS One. 2010 Jan 26;5(1):e8902.

     Jambo KC, Sepako E, Heyderman RS, Gordon SB. Trends Microbiol. 2009 Dec 21.

     Fullerton DG, Gordon SB, Calverley PM. Lancet. 2009 Dec 12;374(9706):1964-5

     Jambo KC, Gordon SB. Thorax. 2009 Sep;64(9):825.

     Mehrotra A, Oluwole AM, Gordon SB. Trop Med Int Health. 2009 Aug;14(8):840-8.

     Fullerton DG, Semple S, Kalambo F, Suseno A, Malamba R, Henderson G, Ayres JG, Gordon SB. Occup Environ Med. 2009 Nov;66(11):777-83. Epub 2009 Aug 10.

     Goonetilleke UR, Ward SA, Gordon SB. Interdiscip Perspect Infect Dis. 2009:214216. Epub 2009 May 27.

     Tam JC, Grant NL, Freire-Moran L, Tolmie H, French N, Gordon SB. J Allergy Clin Immunol. 2009 Jun;123(6):1420-1.

    Etuwewe OM, Swann N, Hollingshead S, Tolmie H, Zijlstra EE, Faragher B, French N, Gordon SB. Vaccine. 2009 Jun 12;27(29):3881-4.

    Fullerton DG, Jere K, Jambo K, Kulkarni NS, Zijlstra EE, Grigg J, French N, Molyneux ME, Gordon SB. Trop Med Int Health. 2009 Mar;14(3):349-54.

     Bell DJ, Dacombe R, Graham SM, Hicks A, Cohen D, Chikaonda T, French N, Molyneux ME, Zijlstra EE, Squire SB, Gordon SB. Int J Tuberc Lung Dis. 2009 Jan;13(1):99-104.

     Mtunthama N, Gordon SB, Kusimbwe T, Zijlstra EE, Molyneux ME, French N. BMC Infect Dis. 2008 Oct 14;8:137.

     Gordon SB, Malamba R, Mthunthama N, Jarman ER, Jambo K, Jere K, Zijlstra EE, Molyneux ME, Dennis J, French N. Vaccine. 2008 Oct 3;26(42):5400-6. Epub 2008 Aug 15

     Fullerton DG, Bruce N, Gordon SB. Trans R Soc Trop Med Hyg. 2008 Sep;102(9):843-51. Epub 2008 Jul 17.

     Wright AK, Briles DE, Metzger DW, Gordon SB. Vaccine. 2008 Sep 8;26(38):4893-903.

     Mtunthama N, Malamba R, French N, Molyneux ME, Zijlstra EE, Gordon SB. J Med Ethics. 2008 Apr;34(4):303-7. 

     Scarborough M, Gordon SB, Whitty CJ, French N, Njalale Y, Chitani A, Peto TE, Lalloo DG, Zijlstra EE.

    N Engl J Med. 2007 Dec 13;357(24):2441-50.PMID: 18077809

     Gordon MA, Gordon SB, Musaya L, Zijlstra EE, Molyneux ME, Read RC. AIDS. 2007 Nov 30;21(18):2399-408.

     Jambo KC, French N, Zijlstra E, Gordon SB. Respir Res. 2007 Jun 13;8:42.

     Gordon SB, Kayhty H, Molyneux ME, Haikala R, Nurkka A, Musaya J, Zijlstra EE, Lindell D, French N. J Allergy Clin Immunol. 2007 Jul;120(1):208-10.

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