EHPC Publications

The Immunological Mechanisms that control Pneumococcal Carriage.
PloS Pathogens. In press. Jochems S.P, Weiser J.N, Malley R, Ferreira D.M.

Pneumococcal Capsular Polysaccharide Immunity in the Elderly
Hugh Adler, Ferreira DM, Stephen B. Gordon, Jamie Rylance Clin Vaccine Immunol. 2017 Jun; 24(6): e00004- 7.  Print 2017 Jun. Review.

A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low income Countries held in Blantyre Malawi.

Gordon SB, Rylance J, Luck A, Jambo K, Ferreira DM, Manda-Taylor L, Bejon P, Ngwira B, Littler K, Seager Z, Gibani M, Gmeiner M, Roestenberg M, Mlombe Y; Wellcome Trust CHIM workshop participants. Wellcome Open Res. 2017 Aug 24;2:70.

Assessing the ideal microwave duration for disinfection of sinus irrigation bottles-A quantitative study.Nikolaou E, Mitsi E, Ferreira DM, Bartolo A, Leong SC.Clin Otolaryngol. 2017 Aug 16. . [Epub ahead of print]

Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a   comparative study (NCT 02515591). Zaidi SR, Collins AM, Mitsi E, Reiné J, Davies K, Wright AD, Owugha J, Fitzgerald R, Ganguli A, Gordon SB, Ferreira DM, Rylance J.BMC Pulm Med. 2017 May 5;17(1):83.

Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash. Jochems SP, Piddock K, Rylance J, Adler H, Carniel BF, Collins A, Gritzfeld JF, Hancock C, Hill H, Reiné J, Seddon A, Solórzano C, Sunny S, Trimble A, Wright AD, Zaidi S, Gordon SB, Ferreira DM. PLoS One. 2017 Jan 20;12(1):e0169805.

Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage. E Mitsi1, AM Roche2, J Reiné, T Zangari, JT Owugha1, SH Pennington, JF Gritzfeld, AD Wright, AM Collins, S van Selm, MI de Jonge, SB Gordon, JN Weiser, DM Ferreira. Mucosal Immunol. 2016 Aug 31.

Polysaccharide-specific Memory B-cells Predict Protection Against Experimental Human Pneumococcal Carriage. Pennington SH, Pojar S, Mitsi E, Gritzfeld JF, Nikolaou E, Solórzano C, Owugha JT, Masood Q, Gordon MA, Wright AD, Collins AM, Miyaji EN, Gordon SB, Ferreira DM.

Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis. Morton B, Mitsi E, Pennington SH, Reiné J, Wright AD, Parker R, Welters ID, Blakey JD, Rajam G, Ades EW, Ferreira DM, Wang D, Kadioglu A, Gordon SB. Shock.

Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization. Blanchette KA, Shenoy AT, Milner J 2nd, Gilley RP, McClure E, Hinojosa CA, Kumar N, Daugherty SC, Tallon LJ, Ott S, King SJ, Ferreira DM, Gordon SB, Tettelin H, Orihuela CJ. Infect Immun. 2016 Sep 19;84(10):2922-32.. Print 2016 Oct.When

When do Coughs and Sneezes Cause Diseases? Gordon S, Ferreira DM. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1329-30. doi: 10.1164/rccm.201601-0130ED. No abstract available.

Oral typhoid vaccination with Ty21a generates Ty21a-responsive and heterologous influenza-responsive CD4+ and CD8+ T-cells at the human intestinal mucosa. Pennington SH, Thompson AL, Wright AK, Ferreira DM, Jambo KC, Wright AD, Faragher B, Gilmour JW, Gordon SB, Gordon MA.

Pneumococcal Colonisation Rates in Patients Admitted to a UK Hospital with Lower Respiratory Tract Infection - a prospective case-control study. Collins AM, Johnstone CM, Gritzfeld JF, Banyard A, Hancock CA, Wright AD, Macfarlane L, Ferreira DM, Gordon SB.

Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles. Kunda NK, Alfagih IM, Miyaji EN, Figueiredo DB, Gonçalves VM, Ferreira DM, Dennison SR, Somavarapu S, Hutcheon GA, Saleem IY. Int J Pharm. 2015 Nov 30;495(2):903-12.

First human challenge testing of a pneumococcal vaccine. Double-blind randomized controlled trial. Collins AM, Wright AD, Mitsi E, Gritzfeld JF, Hancock CA, Pennington SH, Wang D, Morton B, Ferreira DM, Gordon SB. Am J Respir Crit Care Med. 2015 Oct 1;192(7):853-8.

Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage. Glennie S, Gritzfeld JF, Pennington SH, Garner-Jones M, Coombes N, Hopkins MJ, Vadesilho CF, Miyaji EN, Wang D, Wright AD, Collins AM, Gordon SB, Ferreira DM. Mucosal Immunol. 2016 Jan;9(1):56-67.

The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisition. Cremers AJ, Zomer AL, Gritzfeld JF, Ferwerda G, van Hijum SA, Ferreira DM, Shak JR, Klugman KP, Boekhorst J, Timmerman HM, de Jonge MI, Gordon SB, Hermans PW. Microbiome. 2014 Dec 15;2:44.

Detection of high levels of anti-α-galactosyl antibodies in sera of patients with Old World cutaneous leishmaniasis: a possible tool for diagnosis and biomarker for cure in an elimination setting. Al-Salem WS, Ferreira DM, Dyer NA, Alyamani EJ, Balghonaim SM, Al-Mehna AY, Al-Zubiany S, Ibrahim el-K, Al Shahrani AM, Alkhuailed H, Aldahan MA, Al Jarallh AM, Abdelhady SS, Al-Zahrani MH, Almeida IC, Acosta-Serrano A. Parasitology. 2014 Dec;141(14):1898-903.

Density and duration of experimental human pneumococcal carriage. Gritzfeld JF, Cremers AJ, Ferwerda G, Ferreira DM, Kadioglu A, Hermans PW, Gordon SB. Clin Microbiol Infect. 2014 Dec;20(12):O1145-51. Epub 2014 Aug 11.

Mapping of epitopes recognized by antibodies induced by immunization of mice with PspA and PspC. Vadesilho CF, Ferreira DM, Gordon SB, Briles DE, Moreno AT, Oliveira ML, Ho PL, Miyaji EN. Clin Vaccine Immunol. 2014 Jul;21(7):940-8. Epub 2014 May 7.

Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung. Wright AK, Bangert M, Gritzfeld JF, Ferreira DM, Jambo KC, Wright AD, Collins AM, Gordon SB. PLoS Pathog. 2013 Mar;9(3):e1003274.

Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults. Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AK, Pennington SH, Moreno LB, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A, Gordon SB.

Increased IgG but normal IgA anti-pneumococcal protein responses in lung of HIV-infected adults. Collins AM, El Batrawy S, Gordon SB, Ferreira DM 

Experimental human pneumococcal carriage. Gritzfeld JF, Wright AD, Collins AM, Pennington SH, Wright AK, Kadioglu A, Ferreira DM, Gordon SB.

Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage. Ferreira DM*, Wright AK*, Gritzfeld JF, Wright AD, Armitage K, Jambo KC, Bate E, El Batrawy S, Collins A, Gordon SB.. (*contributed equally to the work)

Characterization of the antibody response elicited by immunization with pneumococcal surface protein A (PspA) as recombinant protein or DNA vaccine and analysis of protection against an intranasal lethal challenge with Streptococcus pneumoniae. Vadesilho CF, Ferreira DM, Moreno AT, Chavez-Olortegui C,Machado de Avila RA, Oliveira ML, Ho PL, Miyaji EN. Microb Pathog. 2012 Nov-Dec;53(5-6):243-9.

Controlled inflammatory responses in lungs is associated with protection elicited by a Pneumococcal Surface Protein A-based vaccine against a lethal respiratory challenge with Streptococcus pneumoniae in mice. Lima FA, Ferreira DM, Moreno AT, Ferreira PC, Palma GM, Ferreira JM Jr, Raw I, Miyaji EN, Ho PL, Oliveira ML.

T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice. Neill DR, Fernandes VE, Wisby L, Haynes AR, Ferreira DM, Laher A, Strickland N, Gordon SB, Denny P, Kadioglu A, Andrew PW

Cross-reactivity of antipneumococcal surface protein C (PspC) antibodies with different strains and evaluation of inhibition of human complement factor H and secretory IgA binding via PspC. Moreno AT, Oliveira ML, Ho PL, Vadesilho CF, Palma GM, Ferreira JM Jr, Ferreira DM, Santos SR, Martinez MB, Miyaji EN. Clin Vaccine Immunol. 2012 Apr;19(4):499-507.

Elicitation of mucosal immunity by proteins of Streptococcus pneumonia. Briles DE, Miyaji E, Fukuyama Y, Ferreira DM, Fujihashi K. e. Adv Otorhinolaryngol. 2011;72:25-7.

Experimental human pneumococcal carriage models for vaccine research. Ferreira DM, Jambo KC, Gordon SB. Experimental human pneumococcal carriage models for vaccine research.Trends in Microbiology. 2011 Sep;19(9):464-70.

Nasal immunization of mice with Lactobacillus casei expressing the pneumococcal surface protein C primes the immune system and decreases pneumococcal nasopharyngeal colonization in mice. de Lúcia Hernani M, Ferreira PC, Ferreira DM, Miyaji EN, Ho PL, Oliveira ML FEMS Immunol Med Microbiol. 2011 Apr 14.

Protection against nasal colonization with Streptococcus pneumoniae by parenteral immunization with a DNA vaccine encoding PspA (Pneumococcal surface protein A).Ferreira DM, Oliveira MLS, Moreno AT, Ho PL, Briles DE, Miyaji EN.

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC.

Oliveira MLS, Miyaji EN, Ferreira DM, Moreno AT, Ferreira PCD, Lima F, Santos FL, Sakauchi MA, Takata CS, Higashi HG, Raw I, Kubrusly FS, Ho PL.

Immunization of mice with single PspA fragments induces antibodies capable of mediating complement deposition on different pneumococcal strains and cross-protection. Moreno AT, Oliveira MLS, Ferreira DM, Ho PL, Darrieux M, Leite LCC, Ferreira-Jr JMC, Pimenta FC, Andrade ALSS, Miyaji EN.

The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.Richards L, Ferreira DM, Miyaji EN, Andrew PW, Kadioglu A.

Ferreira DM, Moreno AT, Cianciarullo AM, Ho PL, Oliveira ML, Miyaji EN. Microb Pathog. Sep;47(3):157-63. 2009

Ferreira DM, Darrieux M, Silva DA, Leite LC, Ferreira JM Jr, Ho PL, Miyaji EN, Oliveira ML. Clin Vaccine Immunol. May;16(5):636-45. 2009
 
Campos IB, Darrieux M, Ferreira DM, Miyaji EN, Silva DA, Arêas AP, Aires KA, Leite LC, Ho PL, Oliveira ML. Microbes Infect. Apr;10(5):481-8. 2008
 
Darrieux M, Moreno AT, Ferreira DM, Pimenta FC, de Andrade AL, Lopes AP, Leite LC, Miyaji EN. J Med Microbiol. Mar;57(Pt 3):273-8. 2008
 
Ferreira DM, Darrieux M, Oliveira ML, Leite LC, Miyaji EN. Clin Vaccine Immunol. Mar;15(3):499-505. 2008
 
Darrieux M, Miyaji EN, Ferreira DM, Lopes LM, Lopes AP, Ren B, Briles DE, Hollingshead SK, Leite LC. Infect Immun. Dec;75(12):5930-8. 2007
 
Ferreira DM, Miyaji EN, Oliveira ML, Darrieux M, Arêas AP, Ho PL, Leite LC. J Med Microbiol. Apr;55(Pt 4):375-8. 2006
 
Ferreira DM, Arêas AP, Darrieux M, Leite LC, Miyaji EN. FEMS Immunol Med Microbiol. Mar;46(2):291-7. 2006
 
Miyaji EN, Ferreira DM, Lopes AP, Brandileone MC, Dias WO, Leite LC. Infect Immun. Sep;70(9):5086-90. 2002
Mechanisms causing the inflammatory response to Streptococcus pneumoniae.  Ferreira DM and Gordon SB. Book Chapter of Streptococcus pneumoniae molecular mechanisms and host-pathogen interactions. Elsevier. Jun 2015

 

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