Genome-based diagnostics for mapping, monitoring and management of insecticide resistance in major African malaria vectors (NIAID R01)

Commencing in 2016, our goal is to advance and accelerate the development and application of DNA-based markers for insecticide resistance to enhance the operational use of predictive diagnostics. Working with partners from six groups in West and East Africa, Wellcome Trust Sanger Institute and Oxford, the five year project will involve exploiting the growing whole genome data sets from the , along with genome wide association and laboratory studies to identify novel markers for resistance to multiple insecticides. Following calibration of predictive value, spatial modelling of markers allele frequencies will be applied to produce regional predictive diagnostic maps.